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Atypical Prion Proteins in cattle - SE1796

Description
The pathological phenotype of clinical BSE has been remarkably consistent throughout the epidemic in the British Isles. This has greatly facilitated its surveillance and diagnosis. However, about 15% of the clinically suspect animals submitted for diagnosis were negative by examination of the medulla at the level of the obex for standard histological criteria. Significantly, the numbers of these “negative” suspect cases rose and fell with the number of cases of confirmed BSE as the BSE epidemic progressed, a correlation that remains to be fully explained. One possibility is that, like atypical scrapie cases in small ruminants, these “suspects” represent prion-protein-related diseases with a histopathological and biochemical phenotype that differs from ‘classical’ BSE.
We aim to determine whether abnormal PrP is detectable in these cattle and if it represents an atypical form of bovine prion related disease by applying biochemical tests that facilitate recognition of protease sensitive conformers of PrP. Further characterisation of reactors will be undertaken in order to distinguish normal and abnormal phenotypes of PrP in cattle.
Project Documents
• Final Report - Annex : Atypical prion proteins in cattle   (10064k)
• Final Report - SID5 : Atypical prion proteins in cattle   (201k)
Time-Scale and Cost
From: 2005

To: 2008

Cost: £309,930
Contractor / Funded Organisations
Veterinary Laboratories Agency
Keywords
Animal Health              
Cattle              
Diagnosis              
Plants and Animals              
TSE              
TSEs              
Fields of Study
Animal Health