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Transfer of antimicrobial resistance genes between bacteria in stored and spread farm wastes - OD2008

Description
Objectives:
- To set up a model systems to stimulate storage, treatment and spreading of organic wastes.
- To use marked antimicrobial resistant organsims with known plasmid borne or chromosomal genetic resistance determinants as donors in the above waste processing models.
- To use marked antimicrobial sensitive organisms to act as recipients in artifically contaminated and natural organic wastes.
- To develop quantitative risk assessment (QRA) models to describe the risk of transfer of antimicrobial resistance genes between different bacteria in stored and spread farm wastes.
- To assess the potential for survivial of naked DNA after the death of the organisms, and transfer of antimicrobial resistance genes to other organisms in stored and treated wastes.

Policy Relevance
- Increasing attention on environmental aspects of animal organic waste disposal, in view of intensification of livestock production.
- Greater attention on environmental aspects of animal waste disposal, in view of intensification of livestock production.
- Greater attention worldwide focused on all possible sources of antimicrobial resistance for humans and animals.

Intended use of results
- Results will be used to guide policy and advisory material on storage, treatment and application of organic wastes in relation to grazing/foraging withholding times.
- The QRA models will serve as important sub-models for any overall risk assessment to describe the transfer of antimicrobial resistance from animals to humans.
Objective
01- Assessment of transfer of resistance between organisms in stored farm wastes.

02- Assessment of transfer of resistance in spread farm wastes.

03- Assessment of transfer of resistance in treated farm wastes

04- Assessment of genetic basis of acquired resistance in marked organsisms.

05- Development of models for transfer of resistance.
Project Documents
• Final Report : Transfer of antimicrobial resistance genes between bacteria in stored and spread farm wastes   (266k)
• Executive Summary : Transfer of antimicrobial resistance genes between bacteria in stored and spread farm wastes   (32k)
Time-Scale and Cost
From: 2000

To: 2003

Cost: £386,957
Contractor / Funded Organisations
Veterinary Laboratories Agency
Keywords
Animal Diseases              
Animal Health              
Antimicrobial Resistance              
Bacteria              
Biotechnology              
E.coli O157              
Modelling              
Plants and Animals              
Salmonella              
Fields of Study
Animal Health