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The role of specific dietary fatty acids and antioxidants in modulating circulating lipid profiles and arterial disease. - AN0206

The study represents a programme of experiments designed to provide quantitative information on the influence of specific dietary fatty acids and antioxidants on relevant blood parameters (lipoproteins, cholesterol and triacylglycerol concentrations, clotting factors), cholesterol metabolism and an arterial disease. This initial study will be carried out in hamsters.
1. To assess the effect of different doses of fatty acids in hamsters plasma protein levels and thrombogenic and thrombolytic parameters. 2. To investigate the impact of these effects on artherosclerosis. 3. To examine the additional effects of antioxidants. 4. To use the above information to design the exact protocol for the human study to confirm the predictions made from the animal studies.
Time-Scale and Cost
From: 1992

To: 1995

Cost: £496,262
Contractor / Funded Organisations
University - Nottingham