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The effects of increased dietary polyunsaturated fatty acids on normal immune response. - AN0202

The immunomodulatory role of dietary n3 and n6 polyunsaturated fatty acids and the related monounsaturated fatty acids is to be investigated using three animal model systems; the guinea pig, rat and mouse and a pilot clinical study. The former will generate data on local and systemic immunity in relation to both antibody production and cell mediated immunity, under well defined dietary regimes. The clinical studies will give information on systemic and mucosal immune status of the individual in relation to short term dietary changes in lipid composition
1) Determine the effects of modified PUFA diets on human plasma HDL/LDL/cholesterol levels and assess general immune response. 2) Determine the effects of modified PUFA diets on gastrointestinal/systemic immunoreactivity in guinea pigs. 3) Determine the effects of modified PUFA diets on rat serum chemistry and defined aspects of humoral and cell-mediated immunoreactivity. 4) Investigate the effects of modified PUFA diets on antibody production/suppressor cell activity using a murine model.
Time-Scale and Cost
From: 1991

To: 1993

Cost: £192,939
Contractor / Funded Organisations
Leeds Metropolitan Uni, Dept of Applied