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Development and maintenance of a flock of UK sheep naturally infected with scrapie - SE0230

Description
ROAME Project SE0213 (An epidemiological study of sheep scrapie to determine means of natural transmission) monitored scrapie in farms around the UK. Selected sheep that would otherwise be lost to follow-up were brought from these farms to VLA and were kept together as a single flock at grass.

The result has been an established, diverse flock of known origin, endemically infected with scrapie and presumably with a number of scrapie strains. Such a flock is unique, impossible to replace (many of the source flocks no longer exist) and is a valuable source of material for current and future TSE research studies defined in the MAFF TSE research strategy. This singular research is totally dependent on the scrapie flock and cannot take place in its absence. Continued management of the flock with SE0213 is now considered to be the most efficient and effective approach.

This project will maintain and develop the flock through planned introduction of new breeds, PrP genotypes and through managed breeding so that it continues to support and anticipate DEFRA Policy and VLA TSE research requirements. The costs cover the first 7 years of this project.This revision of the CSG7 contains significant changes over previous versions and these are listed at the start of section 8.
Time-Scale and Cost
From: 2000

To: 2012

Cost: £4,256,934
Contractor / Funded Organisations
Veterinary Laboratories Agency
Keywords
Animal Health              
Epidemiology              
Natural              
Plants and Animals              
Scrapie              
Sheep              
Tissues              
TSEs              
Fields of Study
Animal Health