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What is the potential for human isolates of C. parvum to infect, colonise and be excreted by farm animals - OZ0402

Description
This project aims to study the potential for human isolates of C. parvum genotypes 1 and 2 to infect, colonise and be excreted by farm animal species. Utilising a range of molecular markers, targeting several genes, to genotype and subtype C. parvum isolates and to validate these methods in terms of sensitivity, particularly with regard to mixed genotype 1 and 2 infections and other unusual genotypes. We will seek to answer a number of key questions:
1. Whether both C. parvum genotypes and their various sub-types can infect a range of farm animals including calves, lambs, pigs ?
2. Whether farm animals can excrete a sufficient quantity of oocysts to act as a reservoir / source for the infection of humans or other farm animals?
3. What is the risk of transmission of infection of both genotypes of C. parvum from farm animals to humans, within a defined localised area?
These studies will contribute to answering the question of whether both genotypes can infect, colonise and be excreted by farm animals, and whether the majority of C. parvum infections are derived from animal contact or whether person-to-person transmission (either direct or indirect) is more significant.
Objective
Obj. No. Completed by date Description
01 March 2001 To validate molecular methods for genotyping and subtyping C. parvum isolates, with particular reference to mixed genotype infections and determination of sensitivity.

02 February 2003 To determine the infectivity of C. parvum genotypes 1 and 2 by performing transmission studies into a range of farm livestock (calves, lambs, piglets) with particular emphasis on genotype 1 isolates

03 February
2003 To study links between human infections with C. parvum and animal contacts, by utilising the validated genotyping and typing methods in a limited study in the Avon and Somerset area in collaboration with PHLS.

04 February 2003
The development of initial quantitative risk assessment models to describe the transmission of both genotypes of C. parvum from animals to humans within a defined localised area.
Project Documents
• Final Report : What is the potential for human isolates of both genotypes of C. Parvum to infect, colonise and be excreted by farm animals   (1214k)
Time-Scale and Cost
From: 2000

To: 2003

Cost: £413,005
Contractor / Funded Organisations
Veterinary Laboratories Agency
Keywords
Animal Health              
Biotechnology              
Cryptosporidium              
Epidemiology              
Plants and Animals              
Transmission              
Zoonoses              
Fields of Study
Animal Health