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The effect of antimicrobial treatment and withdrawal on the population dynamics of enteric bacteria expressing resistanc - OD2003(1)

Description
This proposal is written in direct response to the researech requirements outlined in section 77A of the MAFF Animal Health and Welfare Research Requirements 2000-2001. There is considerable concern within the medical profession that antimicrobial agents used in livestock production are major contributors to the ever increasing spectrum of antimicrobial resistance in bacteria of medical importance. In order to minimise the risk of perpetuating antimicrobial resistance by the use of these agents in livestock production, it is essential that effective control strategie are developed. However it is also important thatthese strategies are based on a comprehensive scientific understanding, to ensure that the health, welfare and productivity of livestock is not unnecessarily jeopardised. Consequently we propose to evaluate the effect of treatment with, and subsequent withdrawal of, antimicrobial agents on the acquisition, dissemination and persistence of genes imparting resistance within the bacterial flora of the pig intestine. The study will investigate the effect of four in-feed antimicrobial agents, each with a different resistance mechanism and pharmacokinetic properties, on the expression and persistence of genes impating resistance withinthe bacterial flora of the pig's gastrointestinal tract during and following treatment.
Objective
01: To determine the effect of antimicrobial treatment and subsequent withdrawal on the population dynamics of bacteria expressing antimicrobial resistance within the gastrointestinal tract of the pig
02: To determine the effect of antimicrobial treatment on the emergence of antimicrobial resistance in susceptible bacteria within the gastrointestinal tract of the pig and to determine the genetic mechanism conferring resistance within these organisms.
03: To determine the effect of antimicrobial treatment on the transference of genes conferring antimicrobial resistance carried on mobile genetic elements within enteric bacteria colonising the gastrointestinal tract of the pig.
04: To determine the effect of antimicrobial treatment on the transference of genes conferring antimicrobial resistance and (ii) the fate of the genes encoding resistance within enteric bacterial colonising the gastrointestinal tract of the pig.
05: To determine th eeffect of antimicrobial treatment,as given to pig herds on participating farms, on the resistance profile of enteric bacteria within the gastrointestinal tract.
Time-Scale and Cost
From: 2001

To: 2003

Cost: £350,885
Contractor / Funded Organisations
University - Bristol
Keywords
Animal Diseases              
Animal Health              
Antimicrobial Resistance              
Bacteria              
Biotechnology              
E.coli O157              
Pigs              
Plants and Animals              
Salmonella              
Fields of Study
Animal Health