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To Investigate the Non-Typability of Campylobacters using the LEP Scheme - OZ0601

Recently, a serotyping scheme has been developed at the Campylobacter Reference Laboratory, for human campylobacters. This scheme has been assessed for veterinary campylobacters. Only 60% of poultry strains tested were typable. This non-typability is twice as high for human strains. This significantly reduces the usefulness of this typing scheme to determine the role of poultry campylobacters in human disease and to determine the molecular epidemiology of campylobacter in broiler houses.

The reason for this difference between human and poultry strains will be investigated in this project. In order to this we must determine the extent of non-typability in collaboration with LEP; determine the effect of isolation, growth and storage conditions on non-typability; and identify common phenotypic or genotypic properties in non-typable strains.

This proposal will determine the value of the existing serotyping scheme for poultry campylobacters; provide information about the antigen involved in the LEP typing scheme; and support collaboration between the PHLS and the VLA.
Time-Scale and Cost
From: 1998

To: 1999

Cost: £9,925
Contractor / Funded Organisations
Veterinary Laboratories Agency
Fields of Study
Animal Health