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Genotypic and Phenotypic Instability of Campylobacters from Animal and Human Sources - OZ0605

Description
Campylobacter jejuni/coli are ubiquitous in the environment and asymptotically colonise the intestinal tracts of many animals. Although growth in the environment is unlikely, contamination organisms readily survive and adapt to the stresses of meat processing. The epidemiololgy of Campylobacters is complex and poorly understood. Recently several molecular typing systems have now become available and are being standardised in a European initiative, CAMPYNET. The genetic instability both at the single locus and the whole genome will be investigated using existing outbreak-related isolates from humans and food production animals available from research and reference laboratories throughout the UK. The mechanisms and triggers involved inn genomic instability and its influence on Genotypic, and phenotypic characteristics of strains and therefore the effect of subtyping schemes will be investigated.
Objective
No. Completed by Description
01 01/08/2001 To determine the natural occurrence of genetic and phenotypic instability using up to 200 selected outbreak related and 100 non-outbreak related strains.
02 31/07/2002 To determine the mechanisms underlying campylobacter genotypic variation
Project Documents
• Final Report : Genotypic and Phenotypic Instability of Campylobacters from Animal and Human Sources   (408k)
Time-Scale and Cost
From: 1999

To: 2002

Cost: £298,279
Contractor / Funded Organisations
Veterinary Laboratories Agency
Keywords
Animal Health              
Biotechnology              
Campylobacter              
Plants and Animals              
Transmission              
Zoonoses              
Fields of Study
Animal Health