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`Increasing reproductive efficiency through improved control of follicular growth, oocyte quality and embryo survival` - DS0206
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Objective
1. Isolation and purification of ovarian proteins involved
in the inhibition of growth of subordinate
follicles. Use unique physiologically relevant granulosa
theca cell culture system to purify inhibitory factor
analyse its biological properties. 2. Identification of
underlying mechanisms involved in the nutritional
modification of productive function. Investigate how
insulin and/or IGF-I facilitate the effects of
gonadotrophins on follicular growth and differentiation
using complementary in vivo and in vitro
approaches. 3. Determine role of cytoplasm in oocyte
development as the first step towards oocyte,
and hence embryo quality. This work will provide detailed
information into the physiology of oocyte
maturation and will enable the identification of potential
markers of developmental competence. 4.
Determine effects of nutritional factors on in vivo and in
vitro maturation of cattle and sheep oocytes
and early embryonic development. The effect of nutrition on
oocyte competence and subsequent embryo
development will be determined utilising nutritional
treatments which alter follicular growth patterns.
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Time-Scale and Cost
From:
1996
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To:
1999
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Cost: £1,018,036 |
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Contractor / Funded Organisations
Roslin Institute, Edinburgh (BBSRC) |
Keywords
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Fields of Study
Livestock |