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Markers of oxidized LDL in relation to consumption of vitamin antioxidants and fatty acids ... (formerly AN0235) - AN0443

Objective
1.To determine whether there is a relationship between antibodies to oxidized LDL-cholesterol and habitual consumption of nutrients associated with vitamin antioxidants in the normal population. 2.To determine whether there is a relationship between antibodies to oxidized LDL-cholesterol and habitual consumption of vitamin preparations in the normal population. 3.To determine whether there is a relationship between antibodies to oxidized LDL-cholesterol and habitual consumption of fatty acids assessed by dietary questionnaire and also by fasting plasma fatty acids. 4.To determine whether there is a relationship between the habitual consumption of fatty acids and plasma levels of Lp(a) and ApoA1 & A2. 5.Using an intervention study, to determine whether plasma levels of antibodies to oxidized LDL-cholesterol are influenced at 4 weeks and at 8 weeks by the consumption of modest doses of vitamin antioxidants (*- carotene, vitamin C and vitamin E). 6.To establish whether LDL-oxidizability is influenced by consumption of vitamin antioxidants. 7.To examine the relationship between the presence and levels of antibodies to oxidized LDL-cholesterol and the susceptibility of LDL-cholesterol to oxidation. 8.To determine the effect of using different forms of oxidized LDL (copper oxidized LDL, air oxidized LDL, MDA-modified LDL) as antigen in the immunoassay for antibodies against ox-LDL.
Time-Scale and Cost
From: 1996

To: 1998

Cost: £124,205
Contractor / Funded Organisations
University - Belfast - Queens
Keywords