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Markers of oxidized LDL in relation to consumption of vitamin antioxidants and fatty acids ... (formerly AN0235) - AN0443
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Objective
1.To determine whether there is a relationship between
antibodies to oxidized
LDL-cholesterol and habitual consumption of nutrients
associated with
vitamin antioxidants in the normal population.
2.To determine whether there is a relationship between
antibodies to oxidized
LDL-cholesterol and habitual consumption of vitamin
preparations in the
normal population.
3.To determine whether there is a relationship between
antibodies to oxidized
LDL-cholesterol and habitual consumption of fatty acids
assessed by
dietary questionnaire and also by fasting plasma fatty
acids.
4.To determine whether there is a relationship between the
habitual
consumption of fatty acids and plasma levels of Lp(a) and
ApoA1 & A2.
5.Using an intervention study, to determine whether plasma
levels of
antibodies to oxidized LDL-cholesterol are influenced at 4
weeks and at 8
weeks by the consumption of modest doses of vitamin
antioxidants (*-
carotene, vitamin C and vitamin E).
6.To establish whether LDL-oxidizability is influenced by
consumption of
vitamin antioxidants.
7.To examine the relationship between the presence and
levels of antibodies
to oxidized LDL-cholesterol and the susceptibility of
LDL-cholesterol to
oxidation.
8.To determine the effect of using different forms of
oxidized LDL (copper
oxidized LDL, air oxidized LDL, MDA-modified LDL) as antigen
in the
immunoassay for antibodies against ox-LDL.
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Time-Scale and Cost
From:
1996
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To:
1998
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Cost: £124,205 |
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Contractor / Funded Organisations
University - Belfast - Queens |
Keywords
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