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Measurement of carcinogen DNA and protein adducts using accelerator mass spectrometry an aid to carcinogen risk ases - FS1722

This proposal is concerned with human studies which aim to answer a number of questions concerning carcinogen risk assessment. 1.Show what, if any, correlation exists between blood adducts and those in target organs in man, ie whether or not blood adducts provide an appropriate surrogate dose monitor. 2.Clarify the relevance of animal studies to man. 3.Establish if a threshold exists for adduct formation in man and how this threshold compares with that obtained in experimental animals. 4.Examine dose-response relationships, comparing adduct levels at different doses and making species comparisons. 5.Determine if urine metabolite profiles from man and animals differ; and if so, how.
Time-Scale and Cost
From: 1996

To: 1998

Cost: £375,647
Contractor / Funded Organisations
University of York, Jack Birch Unit