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Development of new methods for safety evaluation of transgenic crops - FS0202

The overall goal is to develop methodologies suitable for evaluating the safety of genetically modified foods. It is focused on test systems suitable for 1) determining the potential allergenicity of newly expressed proteins and modified products; 2) screening whether potential changes in plant metabolism as a consequence of genetic modification may alter the levels of macro and micronutrients as well as natural toxins or anticarcinogens. Information obtained may yeild specific criteria for food safety evaluation of transgenic food crops and thereby assist regulatory authorities.
1. To develop immunoassay systems to detect any specific IgE and IgG antibodies to recombinant novel proteins and transgenic tomatoes after oral induction in the BN rat system. 2. To characterise potentially antigenic determinants. 3. To develop in vitro bioassays for assessing DNA damaging potential to transgenic food crops. 4. To define the conditions under which regulatory approval can be authorised.
Time-Scale and Cost
From: 1994

To: 1998

Cost: £344,982
Contractor / Funded Organisations
BIBRA Toxicology International