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Control of Clostridium difficile: an Emerging Threat to the European Livestock Industry - VM0515

The project will evaluate B. subtilis spores as a feed supplement for competitive exclusion of C. difficile infection as well as non-toxigenic spores of C. difficile. Finally, a novel oral vaccine against C. difficile will be evaluated in pigs. A secondary goal will be to raise awareness of the current threat of antibiotic resistant C.difficile to livestock and ultimately the food chain. Although this pathogen is known, the full importance to European livestock and the resulting food chain has not yet been completely recognized or understood.
To create a feed supplement from B. subtilis spores to competitively control C. difficile.
Explore strategies for reduction and prevention of antibiotic resistance development in C. difficile.
To develop a novel oral vaccine for control of C. difficile.
Time-Scale and Cost
From: 2014

To: 2016

Cost: £367,000
Contractor / Funded Organisations
The Royal Holloway Uni Of London
Veterinary Medicines