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Intelligent ecotoxicology: From single chemicals to mixtures - synthetic Glucorticoid pharmaceutical and reproductive steroid - CB0481

Description
Assess the effects on fish of a synthetic glucocorticoid, a human pharmaceutical which is primarily used as an anti-inflammatory (for example, in treating Asthma).

Investigate the anti-inflammatory and anti-reproductive effects at different doses of glucocorticoids which are known to have undesirable side-effects when blood-levels are chronically elevated (such as during prolonged stress). One side effect is that they have inhibitory effects on reproduction.

Provide data for a synthetic glucocorticoid pharmaceutical, to enhance and complement the existing study which is also concerned with steroidal human pharmaceuticals, synthetic oestrogens, androgens, and progestogens.
Objective
Assess the effects on fish of a synthetic glucocorticoid, a human pharmaceutical which is primarily used as an anti-inflammatory (for example, in treating Asthma).

Investigate the anti-inflammatory and anti-reproductive effects at different doses of glucocorticoids which are known to have undesirable side-effects when blood-levels are chronically elevated (such as during prolonged stress). One side effect is that they have inhibitory effects on reproduction.

Provide data for a synthetic glucocorticoid pharmaceutical, to enhance and complement the existing study which is also concerned with steroidal human pharmaceuticals, synthetic oestrogens, androgens, and progestogens.

Provide the data needed to test a mixture of a reproductive steroid (e.g. a progestogen) and a glucocorticoid

Investigate whether two quite separate suits of responses occur with each one being indicative of one pharmaceutical, or do the two drugs interact in some way to produce unanticipated effects
Time-Scale and Cost
From: 2013

To: 2014

Cost: £30,000
Contractor / Funded Organisations
Brunel University
Keywords
Food Industry Sustainability Strategy              
Fields of Study
Chemicals and Nanotechnology