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Cryogenic Milling. Assessment of the stability of pesticide residues during sample processing - PS2516

Description
In recent years, concerns have been raised at the PRC that residue levels in some samples may have been underestimated due to losses, which could have occurred during the processing of samples of fruit and vegetables, at ambient temperature prior to analysis. It is clearly desirable to develop and adopt sample-processing procedures that eliminate, or at least minimise residue losses, not least because of the implications for both MRL compliance monitoring and consumer risk assessments. Recent work funded by PSD has shown that these losses can be minimised by cryogenic processing, a process that involves comminution of pre-frozen samples in the presence of dry ice.

As a direct result of these findings, cryogenic sample processing is employed for a majority of the commodities in the PRC programme, but is not generally used in other EU member states. There is a need to collate the results of all of the sample processing studies carried out at CSL and to disseminate the findings to the wider scientific community so that other laboratories involved in pesticide residues analysis can make informed decisions regarding sample processing.

The objectives are therefore:
• To review all results on sample processing generated over the last 5 years and produce a discussion document for the PRC.
• To prepare a detailed scientific paper, including statistical analysis of all sample-processing results across all commodities, for submission to a peer-reviewed journal.
• To continue to participate in an IAEA international trial on sample processing with a view to complete the ongoing work on oranges in order to obtain valuable comparative data for ambient and cryogenic sample processing techniques. This project will also provide data on the homogeneity of sample processing which will be required to support the reduction in sample sizes necessary for the introduction of small scale, low cost extraction procedures.
• To prepare a concept note requesting EU funding for an inter-laboratory validation as an effective means of technology transfer.

Objective
1. To review all results on sample processing generated over the last 5 years and produce a discussion document for the PRC.
2) To prepare a detailed scientific paper, including statistical analysis of all sample-processing results from all commodities studied, for submission to a peer-reviewed journal.
3) To continue to participate in an IAEA international trial on sample processing with a view to completing the ongoing work on oranges in order to obtain valuable comparative data for ambient and cryogenic sample processing.
4) To prepare a concept note requesting EU funding for an inter-laboratory validation exercise as an effective means of technology transfer.
Project Documents
• Final Report : Cryogenic Milling. Assessment of the stability of pesticide residues during sample processing   (191k)
Time-Scale and Cost
From: 2004

To: 2005

Cost: £30,043
Contractor / Funded Organisations
Central Science Laboratory
Keywords
Analysis              
Analytical Chemistry              
Analytical Quality Control              
Food Safety              
Method Development              
Monitoring              
Pesticide Residues              
Public Health              
Fields of Study
Pesticide Safety