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Immunology and pathogenesis of bovine respiratory infections - OD1612
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Description
The sustainable, long term control of infectiours diseases of cattle will depend upon vaccination and/or breeding for disease resistance. The application of these measures will mimise or educe reliance on the use of antimicobial componds that are predominantly used in young cattle to control respiratory and enteric diseases. However, it has been difficult to developvaccines against a number of important respiratory pathogens. Furthermore, vaccination against some respiratory pathogens has reulted in enhanced disease. An understanding of the interactions between pathogens, the respiratory mucosa and the innate and acquired immune response will lead to the development of measures that will control calf respiratory disease. In this project, bovine respiratory syncytial virus (BRSV), which is a major cause of pneumonia in young calves will be used to investigate:
- components of BRSV that contribute to the pathogenesis of disease.
- components of the host response that contribute to the pathogenesis of disease.
- how RSV influences the development and duration of acquired immunity.
These studies may lead to the development of improved strategies that will reduce the incidence of respiratory disease due to RS viruses, either through selective breeding for disease resistance or through the development of live attenuated BRSV vaccines. Furthermore the findings from these studies may provide infromation for the development of control measures against other bovine pathogens. This will lead to improvements in calf health and welfare and reduce the use of antimicrobial compounds.
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Objective
01: Rescue of infectious BRSV Snook from cDNA.
02: Rescue for BRS viruses expressing a foreign protein.
03: Analysis of the pathogenicity of rBRS viruses.
04: Analysis of the immunogenic potential of rBRS viruses. |
Project Documents
• FRP - Final Report : OD1612 Final Report
(325k)
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Time-Scale and Cost
From:
2003
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To:
2007
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Cost: £1,080,138 |
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Contractor / Funded Organisations
Institute for Animal Health (BBSRC) |
Keywords
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Fields of Study
Animal Health |