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Examination of genes differentially expressed in immune cells following BSE challenge as a test for TSE infection. - SE1783

Description
Up to now the early molecular events associated with TSE infection have not been studied,as the focus has been on detection of PrPBSE and the events associated with terminal stages of the disease. With the advent of micro-array technology it is now possible to examine the expression profiles for many thousands of genes simultaneously.

The first objective of the project is to assemble an expression array for cattle tailored to the examination of expression profiles in immune cells, which are known to be involved in the establishment of TSE disease. The array will then be used to examine expression profiles in uninfected individuals and animals following a time course of BSE infection. Identification of expression changes occurring soon after infection in blood-born immune cells would provide the best early diagnostic test for TSE infection and surveillance.The genes with altered expression may provide a target for therapeutic intervention.
Project Documents
• Final Report : Examination of genes differentially expressed in immune cells following BSE challenge   (527k)
• Final Report - Annex : Examination of genes differentially expressed in immune cells following BSE challenge - Table 4 of final report   (121k)
Time-Scale and Cost
From: 2003

To: 2007

Cost: £427,602
Contractor / Funded Organisations
Roslin Institute, Edinburgh (BBSRC)
Keywords
Animal Health              
Diagnosis              
Marker              
Plants and Animals              
TSE              
TSEs              
Fields of Study
Animal Health