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Assesment of Manganese Concentrations as a Diagnostic Marker for Prion Disease - SE1774

The aim of this proposal is to assess whether changes in manganese occur in various types of prion disease. We already have strong evidence that there are changes but this need to be confirmed. It shall be assessed in which tissues these changes occur and whether they occur before the onset of symptoms. Controls of other diseases will also be used.Once this has been assessed, we shall develop a rapid technique for detecting manganese concentration using spectrophotometric methods. Tissue for this research will be provided by James Ironside of the CJD Surveillance Unit and will also be obtained from the tissue Archive at the Veterinary Laboratories Agency. Measurements of trace elements in the sample will be carried out in collaboration with Vala Ragnarsdottir of the Department of Earth Sciences at Bristol University.
Project Documents
• Final Report : Final report SE1774   (333k)
Time-Scale and Cost
From: 2002

To: 2005

Cost: £231,952
Contractor / Funded Organisations
University - Bath
Animal Health              
Plants and Animals              
Fields of Study
Animal Health