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Identifying genes from rare breeds for sustainable agriculture - LS3102

A number of diversity studies of livestock species are currently being undertaken. These studies are using DNA markers to characterise average genetic distances between breeds. Such studies do not at present allow us to identify the individual genes that contribute to the value of particular breeds or even evaluate how many such genes there are. The main objectives of this project is to develop and test methodology needed to identify the `footprint` left on the genome by past selection for a gene of value. The project will evaluate the number and type of marker required to be genotyped across the region of a footprint and the best means of analysing the data to visualise the footprint. As a test-bed, the KIT locus in pigs will be studies. It is known that there are three major clades for this locus and it is anticipated that we will identify clear effects of past selection on KIT on the pattern between and within line variation close to the KIT locus. DNA samples collected as part of an EC pig diversity project will be used in the study. The project will allow us to develop an approach for identifying genomic regions where past selection has contributed to the genetic differences between breeds. This will provide conservation organisations with a tool to help evaluate a range of breeds as well as providing breeding companies with a means of identifying genes of potential commercial using samplea from diversity studies.
Project Documents
• Final Report : Identifying genes from rare breeds for sustainable agriculture   (365k)
Time-Scale and Cost
From: 2001

To: 2002

Cost: £16,586
Contractor / Funded Organisations
Roslin Institute, Edinburgh (BBSRC)
Biotech-non GM              
Livestock Farming              
Fields of Study