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Transfer of antimicrobial resistance genes between bacteria in stored and spread farm wastes - OD2008
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Description
Objectives:
- To set up a model systems to stimulate storage, treatment and spreading of organic wastes.
- To use marked antimicrobial resistant organsims with known plasmid borne or chromosomal genetic resistance determinants as donors in the above waste processing models.
- To use marked antimicrobial sensitive organisms to act as recipients in artifically contaminated and natural organic wastes.
- To develop quantitative risk assessment (QRA) models to describe the risk of transfer of antimicrobial resistance genes between different bacteria in stored and spread farm wastes.
- To assess the potential for survivial of naked DNA after the death of the organisms, and transfer of antimicrobial resistance genes to other organisms in stored and treated wastes.
Policy Relevance
- Increasing attention on environmental aspects of animal organic waste disposal, in view of intensification of livestock production.
- Greater attention on environmental aspects of animal waste disposal, in view of intensification of livestock production.
- Greater attention worldwide focused on all possible sources of antimicrobial resistance for humans and animals.
Intended use of results
- Results will be used to guide policy and advisory material on storage, treatment and application of organic wastes in relation to grazing/foraging withholding times.
- The QRA models will serve as important sub-models for any overall risk assessment to describe the transfer of antimicrobial resistance from animals to humans. |
Objective
01- Assessment of transfer of resistance between organisms in stored farm wastes.
02- Assessment of transfer of resistance in spread farm wastes.
03- Assessment of transfer of resistance in treated farm wastes
04- Assessment of genetic basis of acquired resistance in marked organsisms.
05- Development of models for transfer of resistance. |
Project Documents
• Final Report : Transfer of antimicrobial resistance genes between bacteria in stored and spread farm wastes
(266k)
• Executive Summary : Transfer of antimicrobial resistance genes between bacteria in stored and spread farm wastes
(32k)
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Time-Scale and Cost
From:
2000
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To:
2003
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Cost: £386,957 |
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Contractor / Funded Organisations
Veterinary Laboratories Agency |
Keywords
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Fields of Study
Animal Health |