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Effect of dietary fatty acids on CNS mediated responses to injury and infection - AN0204

Dietary intake of fatty acids influences many aspects of the immune system, but the effets on central nervous system (CNS) mediated responses are unknown. The project will investigate the effects of dietary supplementation of n-3 or n-6 fatty acids on these responses in animal (endotoxin, femurfracture, sterile abcess) and human(typhoid vaccune) models of injury and infection. The aims are to compare the effects of fatty acid modification on peripheral (release interleukin 1 and 6 and acute phase proteins) and CNS fuctions (fever, thermogenesis, activation of the hypothalmic-pituitary-adrenal axis) and to assess the mechanisms involved. Changes in tissue, fatty acid composition, cytokine synthesis and actions on CNS will be tested. The findings may allow us to predict the risks and benefits of dietary fatty acid modification on susceptability to and recovery from infection or injury.
1) To assess the magnitude and direction of the metabolic and neuroendocrine responses to injury and infection in response to modification of fatty acid intake in animals and humans. 2) To determine whether such alterations in responses are due to changes in fatty acid composition of the brain, to altered cytokine production or cytokine action on the CNS or pheripheral nervous system.
Time-Scale and Cost
From: 1991

To: 1993

Cost: £88,131
Contractor / Funded Organisations
University - Manchester