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Delta-6-desaturase activity, dietary factors and coronary heart disease.Nutritional approaches to prevention. - AN0201

Low levels of linoleic acid metabolites, including dihomo-gamma-linoleic (CHD) mortality.Large food supplements of linoleic acid in subjects with low DHLA do not increase DHLA. Gamma-linoleic acid, which does not depend on delta-6-desaturase (delta-6-desat) for its conversion, does increase DHLA, suggesting a block in delta-6-desat. Most of our current knowledge of factors that determine delta-6-desat is derived from animal studies, showing marked species differences. Human data is virtually non-existent and there is a need to develop simpler direct methods to study the role of delta-6-desat metabolites in CHD in man. We will examine the influence of dietary fat (saturated, trans-unsaturated and poly-unsaturated) and of ther classical risk factors on delta-6-desat and delta-5-desat in Scottish men. The results may form the basis of adequate dietary advice of new food supplements that could be of value to reduce CHD.
1) To develop more practical methods to study D-6-desaturase (d-6-desat) and D-5-desaturase (d-5-desat) in man. 2) To study the relationship between dietary factors and the activity of d-6-desat and d-5-desat in man. 3) To study the relationship between classical risk factors and the desaturase activities.
Time-Scale and Cost
From: 1991

To: 1994

Cost: £209,382
Contractor / Funded Organisations
University - Edinburgh