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Influence of complex carbohydrate foods on gastrointestinal endocrine mechanisms. - AN0101

The general objective of this project is to acheive a greater understanding of the mechanisms of action of the various forms of non-starch polysaccharides(NSP). A specific aim is to test the hypothesis that soluble and fermentable components of NSP xert some of their most important physiological effects through the release of gastrointestinal (GI) regulatory peptides. Well defined PS with known rheological properties and susceptibility to fermentation by colonic micro-organisms will be evaluated for their effects on GI peptides in experimental animals and man. It is intended that the project will lead to a relatively simple physiological approach by means of which the biological effects and benefits of new products or novel sources of dietary fibre could be evaluated in human subjects.
1. To investigate the efffects of defined soluble NSPs and oligosaccharides on the release of enteroglucagon, gastrin, neurotensin and insulin over time in the rat. 2. To establish the mechanism of release and in particular to distinguish effects due to changes in luminal rheology from those due to fermentation of carbohydrate in the large bowel. 3. To evaluate the possible significance of enteroglucagon in relation to hepatic cholesterol synthesis in the rat. 4. To compare the effects of selected materials in experimental animals with those in man, by means of acute feeding trails.
Time-Scale and Cost
From: 1991

To: 1994

Cost: £204,372
Contractor / Funded Organisations
IFR - Institute of Food Research (BBSRC)