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The evaluation and development of management practices to delay the onset of anthelmintic resistance - OD0541

Parasitic gastroenteritis (PGE) continues to be a welfare problem in cattle and sheep, causing ill thrift, loss of production and death, and the disease’s epidemiology continues to evolve in response to changes in climate, animal management and husbandary, and other factors, including drug usage.

The regular use of any chemical to control infective organisms poses the risk of development of resistant populations and a subsequent threat to animal welfare. Resistant nematodes in sheep and goats have been reported and are widespread throughout the main sheep-rearing areas of the world. Anthelmintic resistance in Europe has been slower to develop for a number of reasons but the threat of loss of effective drugs remains. To counter the development of resistance, control measures have been devised and recommended. A computer model for predicting the rate of development of resistance in sheep nematodes is under development in project OD0529. The model will be run and validated to determine the theoretical optimal dosing and management strategies for limiting the development of resistance. Model validation will require data from on-farm studies employing currently recommended control measures designed to maximise the efficacy of the anthelmintic, whilst reducing the selection pressure for development of resistance.
The project will ultimately lead to the production of revised guidelines for delaying the development of anthelmintic resistance in nematodes of sheep.

Project Documents
• Final Report : The evaluation and development of management practices to delay the onset of anthelmintic resistance   (983k)
Time-Scale and Cost
From: 2000

To: 2003

Cost: £168,297
Contractor / Funded Organisations
Veterinary Laboratories Agency
Animal Diseases              
Animal Health              
Plants and Animals              
Fields of Study
Animal Health