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Immunopathogenesis of classical swine fever - SE0764

Description
It is not known how classical swine fever virus (CSFV) causes disease, nor why some strains ofthe virus cause more serious infections than others. Since the virus does not kill the cells in which it replicates, it is anticipated that the damage caused in vivo is due to indirect effects including activation of immunological responses. The objective of this project is to define some of the mechanisms which contribute to cellualr dysfunction, delayed immunity and severe disease when pigs are infected with CSFV. Thia will also provide an opportunity to define the factors which determine viral virulence.

Classical swine fever is a list A disease that continues to pose a threat to the pig industries of Europe, including Great Britain. recent large scale epidemics have caused enormous losses and emphasise MAFF's commitmnet to maintaining expertise and research into this disease. This is necessary, not only to ensure prompt and accurate diagnosis for suspect cases, but also to continue the development of improved methods of control.

A better understanding of the mechanisms by which CSFV causes disease will help to differentiate virulent and non-virulent viruses and contribute to the development of a new generation of safe and effective live vaccines. These are needed for the development of marker vaccines that can elicit a powerful protective immunity.
Objective
01 9-01 To determine the effects of CSFV on NFkB activation and apoptosis in porcine marcophages in vitro.

02 9-02 To determine the effects of specific proteins encoded by CSFV on NFkB activation and apoptosis in porcine macrophages in vitro.

03 9-03 To identify porcine macrophage protein(s) which interact with protein(s) encoded by CSFV.
Project Documents
• Final Report : Immunopathogenesis of Classical Swine Fever   (53k)
Time-Scale and Cost
From: 2000

To: 2003

Cost: £379,840
Contractor / Funded Organisations
Institute for Animal Health (BBSRC)
Keywords
Animal Diseases              
Animal Health              
Biotechnology              
Classical Swine Fever              
Pathogenesis              
Plants and Animals              
Fields of Study
Animal Health