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Development of badger vaccines - SE3210

Description
This proposal addresses MAFF’s research requirement to develop improved strategies to reduce herd breakdown (ref: RRD 92H). The Krebs report (1) recommended that the best prospect for control of bovine tuberculosis is the development of a cattle vaccine; with the option of a badger vaccine being retained. As a prequel to the testing of novel vaccines in badgers, we shall work in collaboration with the Republic of Ireland to conduct a prototypical badger immunisation trial using BCG Pasteur. The practical difficulties of delivering a badger vaccine in the wild makes oral vaccination an attractive approach. We shall identify vaccine formulations and delivery strategies suitable for oral vaccination of badgers. The alternative to an oral vaccine delivery strategy is a single-shot parental injection. We therefore propose to identify vaccine formulations suitable for non-oral delivery to badgers. The possibility of immunotherapy of existing disease by vaccination will also be explored. Since it is not yet feasible to test candidate vaccines in the badger, the proposed project will utilise an appropriate small animal to model vaccination strategies: a mouse challenge model will be used for immunoprophylaxis studies; and a mouse pre-infection model will be used for immunotherapy studies.
Objective
Obj. No. Completed by date Description

01
VLA/EIRE
18/01/2000
Immunisation studies performed in badger with BCG Pasteur.



02
VLA/CSL/APS
31/03/2002
Vaccines formulated for mucosal delivery via the oral route.



03
VLA
31/03/2001
Most immunogenic formulation identified for parenteral vaccination.



04
VLA
31/03/2002
Candidate badger vaccines tested for their protective and/or therapeutic efficacy in a mouse M. bovis-challenge model.


05
VLA
30/11/2001
T-cell antigens identified as candidates for subunit vaccines for cattle, tested using blood from M. bovis-infected badgers.


06
VLA
29/03/2002
Annual progress reports, publications, and final report produced.


Project Documents
• Final Report : Development of badger vaccines   (1523k)
• Executive Summary : Development of badger vaccines   (121k)
Time-Scale and Cost
From: 1999

To: 2002

Cost: £370,274
Contractor / Funded Organisations
Veterinary Laboratories Agency
Keywords
Animal Health              
Biotechnology              
Bovine Tuberculosis              
Control              
Genetically modified food and crops              
GM Non-Food              
Plants and Animals              
Vaccines              
Zoonoses              
Fields of Study
Animal Health