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The role of the pre-impantation embryo in the vertical transmission of natural scrapie infection - SE1834

The objective of this project is to determine the role of the pre-implantation stage embryo in the vertical transmission of natural scrapie. Scrapie is one of a group of diseases called transmissible spongiform encephalopathies (TSE`s). The presence of TSE`s in the national flock costs the agricultural industry millions of pounds in lost revenue.The UK also loses further money in agricultural compensation.The possibility of the TSE contamination of human foodstuffs has also given rise to widespread public health concerns.

Once the mode of vertical transmission of natural scrapie infection is determined the results can be used:

a)To provide advice and a model to allow the possible reduction in levels of TSE infection in the national flock.This information will supplement earlier DEFRA funded BSE transmission studies at High Mowthorpe.

b)To allow informed decisions to be made by import/export regulatory authorities on the relative risks of importing disease in embryos from infected flocks/countries.

c)To possibly increase UK agricultural exports.
Project Documents
• Final Report : Final report   (197k)
Time-Scale and Cost
From: 1998

To: 2006

Cost: £988,502
Contractor / Funded Organisations
University - Scottish Agricultural College
Animal Health              
Plants and Animals              
Fields of Study
Animal Health