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Characterisation (by transmission to mice) of BSE from experimentally infected sheep of different PrP genotypes. - SE1429

Description
The main objective of this work was to establish whether natural scrapie and BSE could be distinguished within the body of a single sheep, and in mice following the transmission of three mixed inoculations of BSE and a natural scrapie isolate.

The remaining work involves strain-typing from brain of one of the BSE experimentally infected sheep (42x81),in which primary transmission was not BSE-like, and from the transmission of mixed BSE/NPU Cheviot natural scrapie to mice. This should establish whether BSE can be identified from a mixed TSE inoculum.

These results will provide data to help examine the possibility that BSE may have infected the UK sheep flock, by characterisation from mixed TSE sources.
Project Documents
• FRP - Final Report : Final Report   (73k)
Time-Scale and Cost
From: 1998

To: 2008

Cost: £808,485
Contractor / Funded Organisations
Roslin Institute, Edinburgh (BBSRC), Institute for Animal Health (BBSRC)
Keywords
Animal Health              
Bio-assay              
BSE              
Lesion Profile              
Plants and Animals              
Strain              
Transmission              
TSEs              
Fields of Study
Animal Health