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Genetic basis of susceptibility to myeloid leukosis induced by subgroup J avian leukosis viruses - OD0708(1)

Description
The project concerns further studies on subgroup J avian leucosis virus (ALV) which causes serious losses from myeloid leucosis (ML) in commercial meat type breeding lines of chickens. The project will investigate the molecular epidemiology of the disease caused by variant viruses, an lyses the pattern of inheritance of genetic resistance among different inbred and commercial lines of chickens and try to understand the molecular basis of oncogenecity and genetic susceptibility to ML induced by subgroup J ALV. Studies will include in vitro transformation assay of monocytes using acute transforming variants of subgroup J ALV, which could provide a simple and rapid ,means of identifying resistant birds.
T he project will:

- contribute to the scientific knowledge and control of an economically important new virus and disease in meat-type chickens
- contribute to poultry welfare by reducing mortality
- contribute to wealth creation by reducing economic loses from disease in poultry
- help maintaining scientific expertise and techniques necessary for control of ALV
- be transferred to commercial poultry breeding companies for use in genetic selection programmes.
Time-Scale and Cost
From: 1998

To: 2001

Cost: £445,447
Contractor / Funded Organisations
Institute for Animal Health (BBSRC)
Keywords
Animal Diseases              
Animal Health              
Neoplastic              
Pathogenesis              
Plants and Animals              
Fields of Study
Animal Health