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Epidemiological studies of multiple resistant S.typhimurium DT 104 infection in cattle - OZ0135

The aims of this project are to:
1) provide an understanding of the epidemiology of multiple-resistant S. typhimurium DT 104 infection in cattle herds;
2) develop suitable practical preventive measures to protect herds from infection;
3) field test the effectiveness of these preventive measures in a large-scale intervention trial.
It is hoped that, as a result of this work, practical preventive measures can be recommended to reduce the incidence of S. typhimurium DT 104 infection in cattle. The adoption of effective preventive measures will increase the profile of MAFF within the cattle community, reduce the burden of disease on farmers and improve animal welfare. There may also be a potential benefit to the human population through improved public health if salmonellosis acquired from cattle sources can be reduced.
Obj. No. Completed by date Description
01 30.10.1998 Stm DT 104 in cattle: disease recurrence study
Cattle herds with evidence of disease due to multiple-resistant S. typhimurium DT 104 infection identified during the case-control study will be followed up to determine the risk factors that are associated with repeat episodes of clinical disease. A comparison will be made to the repeated incidence of disease in the control herds during the same period.
02 30.09.1999 Stm DT 104 in cattle: application of molecular strain differentiation techniques to repeat episodes of herd infection
Salmonella isolated during repeat episodes of herd infection will be compared using genetic typing techniques to distinguish between persistent herd infection and the introduction of new infection.
03 30.09.1999 Stm DT 104 in livestock: case cluster analysis
Space and time case cluster analysis of reported multiple-resistant S. typhimurium DT 104 infection in cattle, pigs and poultry units will be conducted to establish whether incidents between species are associated.
04 30.09.2001 Stm DT 104 in cattle: prevalence and intervention study
A prevalence study will be undertaken and, if feasible, recruited herds will be followed longitudinally in an intervention trial to establish the effectiveness of preventive measures proposed from previous work to control Stm DT 104 infection in cattle.
05 30.03.2001 Stm DT 104 in cattle: longitudinal studies of individual animal prevalence on infected farms
The objective is to assess the individual animal prevalence in infected herds during and following outbreaks of reported disease.
06 06.09.1999 Feasibility study
Prior to the intervention trial being conducted, a survey will be carried out of major disease security and hygiene parameters on a random sample of cattle farms to establish baseline levels and to investigate the likely level of uptake of advice on farm hygiene improvements to prevent/control salmonellosis and other important endemic diseases (including E. coli O157).
In addition, the impact of the recent reduction in incidence on Objective 04 study plans will be evaluated in the light of further information on the prevalence of Stm DT 104 in the national cattle population (e.g. from the VLA salmonella database and the VLA abattoir survey for zoonoses, FSZ-ECO).
Project Documents
• Final Report : Epidemiological studies of multiple-resistant salmonella typhimurium DT 104 infection in cattle   (108k)
Time-Scale and Cost
From: 1997

To: 2002

Cost: £523,530
Contractor / Funded Organisations
Veterinary Laboratories Agency
Animal Health              
Plants and Animals              
Fields of Study
Animal Health