Defra - Department for Environment, Food and Rural Affairs.

Science Search

Science and Research Projects

Return to Science Search homepage   Return to Project List

biomarkers of reactive nitrogen species. Their role in genotoxicity and the effect of diet - FS1729

Objective
1. To investigate levels of nitrate and nitrite in human body fluids and the effect of diet. 2. To determine whether peroxynitrate nitrates polyphenols present in this process can inhibit the nitration of tyrosine. 3. To measure nitrotyrosine as a marker of peroxynitrite generation in vivo and examine the effect of diet. 4. To develop markers of genotoxicity of reactive nitrogen species.
Time-Scale and Cost
From: 1996

To: 1999

Cost: £361,482
Contractor / Funded Organisations
United Med&Dental Sch. Free Radical Res., University - London - Kings College
Keywords