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Transmission studies for the detection of BSE in sheep - SE1423

Description
The main objective is to look for evidence of ESE infection of sheep by carrying out transmissions to mice from sheep of PrP genotypes susceptible
to BSE but resistant to scrapie.
* The work will address MAFF policy requirements in relation to the risk of BSE to other species of domestic animals and epidemiological changes
requiring further action.
* Samples of brain tissue from scrapie affected animals will be collected and stored under conditions suitable for subsequent transmission
* PrP genotyping will be carried out on DNA made from the samples
* Transmissions to a panel of mouse lines will be initiated from up to ten individual brain samples from animals found to be of genotypes known to be susceptible to BSE.
* Transmissions to a panel of mouse lines will be initiated from up to ten individual brain samples from animals found to be of genotypes known to be susceptible to scrapte as controls.
* Incubation periods and lesion profiles will be recorded from the mouse panel and compared with those obtained from similar previous studies of ESE and scrapie.
Project Documents
• Final Report : Transmission studies for the detection of BSE in sheep   (131k)
Time-Scale and Cost
From: 1996

To: 2002

Cost: £717,000
Contractor / Funded Organisations
Institute for Animal Health (BBSRC)
Keywords
Animal Health              
BSE              
Plants and Animals              
Scrapie              
Sheep              
Strain              
Transmission              
TSEs              
Fields of Study
Animal Health