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Investigation of the role of the embryo in maternal transmission of scrapie in sheep. - SE1823

Description
The MAFF Open Contract on Investigation of the role of the embryo in maternal transmission of scrapie in sheep, has now formally come to an end although the work initiated has to go on for another six years to be completed.

There are at present 121 surviving sheep of various ages and Sip/PrP genotypes which, as part of the experiment, are being maintained by IAH (see attached table).

Important observations from these sheep which relate to the aetiology of scrapie.

There is the probability that scrapie is an infectious disease and does not have a purely genetic origin. This is being assessed by the longevity of highly susceptible sheep (Sip sAsA, currently >1350 days old), which had they been born and reared normally in the NPU Cheviot flock could be expected to develop natural scrapie at about 800 days of age.

A better understanding of the timing of scrapie transmission from an infected ewe to her offspring, either as a result of in utero or peri?/ post?natal infection may emerge. It is essential that the work which has already been funded should be maintained until completion over the next six years by additional funding.
Project Documents
• Final Report : Final report   (30k)
Time-Scale and Cost
From: 1995

To: 2001

Cost: £226,881
Contractor / Funded Organisations
Institute for Animal Health (BBSRC)
Keywords
Animal Health              
Embryo              
Maternal              
Plants and Animals              
Scrapie              
Transmission              
TSEs              
Vertical              
Fields of Study
Animal Health