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`Increasing reproductive efficiency through improved control of follicular growth, oocyte quality and embryo survival` - DS0206

1. Isolation and purification of ovarian proteins involved in the inhibition of growth of subordinate follicles. Use unique physiologically relevant granulosa theca cell culture system to purify inhibitory factor analyse its biological properties. 2. Identification of underlying mechanisms involved in the nutritional modification of productive function. Investigate how insulin and/or IGF-I facilitate the effects of gonadotrophins on follicular growth and differentiation using complementary in vivo and in vitro approaches. 3. Determine role of cytoplasm in oocyte development as the first step towards oocyte, and hence embryo quality. This work will provide detailed information into the physiology of oocyte maturation and will enable the identification of potential markers of developmental competence. 4. Determine effects of nutritional factors on in vivo and in vitro maturation of cattle and sheep oocytes and early embryonic development. The effect of nutrition on oocyte competence and subsequent embryo development will be determined utilising nutritional treatments which alter follicular growth patterns.
Time-Scale and Cost
From: 1996

To: 1999

Cost: £1,018,036
Contractor / Funded Organisations
Roslin Institute, Edinburgh (BBSRC)
Fields of Study