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Evaluation of the effects of dietary supplements of individual fatty acids on vascular tone and endothelial - AN0233

1. Enrolment of N=35 healthy subjects (men and women aged 40-65, non-smokers) to each of 6 study arms. 2. Assessment of baseline dietary essential fatty acid status in 210 study subjects. 3. Assessment of baseline vascular tone with particular interest in the role of the vascular endothelium. 4. Assessment of baseline endothelial function by measurement of plasma endothelin and thromoboglobulin, assessment of NO production by white blood cells. 5. Dietary supplementation of essential fatty acids by mouth (olive oil, evening primrose oil, Soya bean oil, tuna fish oil and EPO/tuna oil mix). 6. Evaluation of the effects of 8 months supplementation on the tests outlined in 2) -5) above.
Time-Scale and Cost
From: 1996

To: 1999

Cost: £437,812
Contractor / Funded Organisations
University - Dundee