Defra - Department for Environment, Food and Rural Affairs.

Science Search

Science and Research Projects

Return to Science Search homepage   Return to Project List

Relationship between conformation of PrP, infectivity and pathogenicity of BSE as a basis for diagnosis. - SE1728

This application is for covering 50% funding for an agreed EU FAIR 5 project No. CT97 ? 3314 involving VLA, the universities of Munich and Gottingen, the CNRS Laboratories in Paris and Connex GMBH of Munich. The project seeks to determine the molecular properties of PrPc, PrPbse and PrP?peptides in order to study the relationship of conformation with strain characteristics, pathogenesic behaviour and ligand interaction as a basis for the development of diagnostic aids in the disease itself and exposed animals. The major role for VLA is the preparation, purification and characterisation of PrPbse from clinically affected animals and the supply of such materials to collaborating scientists. In addition, antibodies to the various forms of PrP and to required PrP peptides will be produced and supplied. The development of diagnostic procedures for the disease itself, for the presence of characterised forms of PrPsc and for the detection of exposed animals is a central requirement for MAFF for the control, management and risk assessment aspects of the epidemic. The details supplied in this ROAME cover the work to be carried out with MAFF funding and the costings therefore also relate to MAWs contribution only.
Project Documents
• Final Report : Final Report   (97k)
Time-Scale and Cost
From: 1996

To: 2001

Cost: £499,515
Contractor / Funded Organisations
Veterinary Laboratories Agency
Animal Health              
Plants and Animals              
Fields of Study
Animal Health