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Effect of secondary bile acids & butyrate on the expression of c-myc & genes regulating apoptosis in colon epith cells - AN0313

Objective
1.To determine the effect of a range of secondary BAs and butyrate upon the rate of cell proliferation and apoptosis in primary cultures of normal colonic epithelial cells, adenoma cells and carcinoma cells. 2.To determine the effect of secondary BA and butyrate upon the activation of protein kinases involved in mitogenic and apoptosis signalling pathways. 2.To determine the effect of BA and butyrate upon the expression of genes associated with cell proliferation and apoptosis.
Time-Scale and Cost
From: 1995

To: 1998

Cost: £190,135
Contractor / Funded Organisations
University - Birmingham
Keywords