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Increased intakes of polyunsaturated fatty acids and vitamin E in relation to oxidative stress ... (formerly AN0225) - AN0442

In response to nutrirional advice, in recent years the UK population has increased intakes of polyunsaturated fatty acids (PUFAs) at the expense of saturated fatty acids. However, PUFAs are extremely susceptible to free radicle-mediated peroxidation and enhanced intakes may compromise the body's antioxidant defence mechanism and lead to increased lipid peroxidation in vivo. Instead lipid peroxidation in vivo. Increased lipid peroxidation is implicated in many diseases including coronary heart disease. This study will assess (1) whether increased intakes of PUFAs include elevations in indices of oxidative stress in plasma, red cells, platelets of human volunteers with subsequent detrimental changes in function and (2) whether any such changes can be prevented or ameliorated by a concomitant increase in vitamin E intake, the major lipid soluble antioxidant in the human diet.
The effect of low antioxidant intakes in relation to endogenous oxidant loads is a major concern in the study of the pathogenesis of many diseases including coronary heart disease and certain cancers. However at present little data is available to allow elimination of the optimum antioxidant intakes required to reduce morbidity and premature mortality. This preliminary study will ultimately provide a rational basis for the setting of nutritional guidelines relating optimum vitamin E intakes to the consumption of PU FAs and thus assist established nutritional policy formulated by the government to achieve the defined health targets.
Time-Scale and Cost
From: 1994

To: 1997

Cost: £426,503
Contractor / Funded Organisations
Rowett Research Institute