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Geographical distribution and incidence of anti-coagulant resistance in rats (Previously VC0301) - VC0309

Resistance to anticoagulant rodenticides can have considerable adverse effects on the outcome of rodent control treatments. Anticoagulant-resistance rats have been found throughout the UK; however, it is not known if these are isolated infestations or examples of a deep-rooted problem. A high prevalence of resistance has been found in and around pig and poultry units. This study will aim to identify geographical locations where rat infestations include anticoagulant-resistant individuals, to establish the degree of resistance of these rats to first- and second-generation anticoagulant rodenticides, and to monitor changes in resistance status. Rats from pig and poultry units, or other farm types if heavy infestations cannot be found, will be sampled throughout the UK. Areas not investigated previously will be examined for the presence of anticoagulant-resistance, while temporal changes in resistance status of rats from known hot-spots of anticoagulant-resistance will be monitored. A small breeding programme will also be carried out in order to determine whether wild-caught rats possess inherited resistance traits. Results will provide information on the distribution, prevalence and degree of resistance to at least 5 anticoagulant rodenticides in rats.
a)To use existing and previous work to identify geographical locations where Rat infestations Include anticoagulant-resistant individuals. b)To establish the degree of resistance of those rats to first and second-generation anticoagulant rodenticides. c)To monitor any changes in resistance status compared to previous samples.Work towards meeting all three scientific objectives will begin in April 1995 and continue until March 1998.
Time-Scale and Cost
From: 1995

To: 1998

Cost: £333,682
Contractor / Funded Organisations
Central Science Laboratory
Fields of Study
Wildlife Management