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Effect of different dietary carbohydrates on colon function: Design of healthier foods. - AN0310
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Description
The proposal represents part of a multidisciplinary
collaboration, part funded by EC, to identify complex
carbohydrates (CHO) with potential beneficial effects on
colon cancer. As in vitro continuous culture model of the
human colonic flora will be used to study the profile of
short chain fatty acid (SCFA) producton from a wide variety
of CHO. The results, in combination with information from
collaborating laboratories on the SCFA profiles likely to
confer greatest benefical effects on the colon, will be used
to design studies in germ free rats associated with
complete human gut microfloras. Novel assays for DNA damage
and preneoplastic lesions in the colon will be used to
assess protective effects of CHO in vivo. Intervention
trials with CHO, identified by the above studies, will be
conducted in familial polyposis and colon cancer patients,
by our collaborating laboratories. |
Objective
The overall objectives of the collaborative research
programme are:-
1) To develop a scientific basis for the identification of
those complex carbohydrates having a protective or ameliora
ting effect on chronic colonic disease, particularly colon
cancer.
2) to aid the prediction of health benefits from novel
carbohydrates by simple in vitro fermentation data.
3) To provide data for use in dietary recommendations relat
ing to carbohydrates with specific health promoting effects
4) To provide information to enable food manufacturers to
develop complex carbohydrates-containing foods with health
promoting properties. |
Time-Scale and Cost
From:
1994
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To:
1997
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Cost: £468,293 |
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Contractor / Funded Organisations
BIBRA Toxicology International |
Keywords
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