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Accummulation and fate of blue-green algal toxins in fish. - FS2035

Description
Trout would be exposed to blue-green algal hepatotoxins and neurotoxins encountered in UK waterbodies, both as free toxins in water and as toxic blue-green algal cells. Toxin localization would focus on fish flesh and liver. The possiblities of toxin metabolism and persistance in the fish would also be investigated. All treatments would include toxin levels, types and exposure times which occur in aquatic environments.
Objective
1. To produce stocks of labelled toxic algae and of labelled hydrophilic and hydrophobic microcystins, anatoxin-a and saxitoxin. 2. To optimise microcystin and neurotoxin recoveries from fish. 3. To determine toxin accumulation in fish flesh and liver in relation to environmentally-relevant levels, exposure times and tissue concentrations. 4. To determine whether toxin-exposed fish can clear toxins when transferred to toxin-free water. 5. To determine whether accumulated toxins are metabolised, identify products and determine toxicity relative to original toxins.
Time-Scale and Cost
From: 1994

To: 1997

Cost: £212,689
Contractor / Funded Organisations
University - Dundee
Keywords