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Does iron supplementation together with vitamin C supplement -ation enhance bioavailability of iron in vivo ? - AN0513

Description
THe purpose of this project is to investigate the bioavailability of iron in vivo, its relationship to the nature of the iron supplement and the effects of additional combined supplementation with vitamin C in predisposing to oxidative stress. In a human volunteer study we plan to monitor the consequences of iron supplementation at the high end of recommended levels with and without supplementation with 60mg vitamin C. The effects on the blood vitamin C levels, platelet function and the oxidisability of low density lipoproteins, as well as on the serum iron levels andurinary iron excretion will be examined. For ethical reasons it is not possible to study a wide range of iron-with-vitamin C supplements in human volunteers. Therefore the ability of vitamin C to enhance iron bioavailability and iron toxicity will be studied in a guinea pig model and in cultures cells as a function of relative concentrations of vitamin C and iron.
Objective
1. To investigate the bioavailability of iron in vivo and the effects of additional combined supplementation with vitamin C in predisposing to oxidative stress. 2. To allow an indication of the level of safety of vitamin C supplements and the establishment of safe combination supplemental levels of iron and vitamin C.
Time-Scale and Cost
From: 1994

To: 1997

Cost: £255,049
Contractor / Funded Organisations
United Med&Dental Sch. Free Radical Res.
Keywords