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Selenium intake: effect on selenoprotein function - AN0512

The objective of this study is to clariy the biochemical function of selenium in man. Supplementation of volunteers with organic and inorganic forms ofselenium will give information on which to base dietary recommended values for the UK.
1. To determine the relative effectiveness of organic and inorganic forms of selenium in changing total and functional selenium status in humans. 2. To obtain information on functional effects of changes in selenium status in the UK population. i) can plasma/blood glutathione peroxidase activities be increased by selenium supplementation and does this change plasma antioxidant status. ii) to find out whether thyroid function can be modulated by changes in selenium intake in a Western population.
Time-Scale and Cost
From: 1994

To: 1997

Cost: £237,224
Contractor / Funded Organisations
Rowett Research Institute