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Dietary fish oil supplementation in man and insulin sensitivity. - AN0222

To test the hypothesis that a diet supplemented with fish oil in the range of reported dietary intakes, will in a dose-related manner: 1. cause an increased incorporation of n-3 long chain fatty acids into triacylglycerols and phospholipids of human muscle and adipose tissue, 2. enhance metabolic clearance of glucose and diminish hepatic production of glucose during euglycaemic hyperinsulinaemia, 3. increase whole body and fat oxidation in the post-absorptive state, 4. increase glucose uptake into muscle and have either no effect or decrease it into adipose tissue, 5. increase the amount of insulin receptor and insulin receptor substrate proteins, and their degree of phosphorylation in plasma membranes of skeletal muscle but not adipose tissue. 6. increase the expression of the glucose transporter GLUT4, and its recruitment to the plasma membrane during hyperinsulinaemia in muscle, 8. show effects not only in normal subjects but also in individuals with a predisposition to diabetes and in patients with diet treatable non-insulin dependent diabetes mellitus (NIDDM).
Time-Scale and Cost
From: 1994

To: 1995

Cost: £156,206
Contractor / Funded Organisations
University - Dundee