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Mechanisms where by fats modulate cytokine production by immune cells. - AN0214

Current health proposals recommend substantial changes in the quantity and type of fat consumed by the population of the UK. Fats modulate cell mediated aspects of immune function. Recent studies show that fish oils moduate production of key cytokines, such as interleukin (IL1) and tumour necrosis factor (TNF), which influence immune function and inflammatory processes. The present proposal will extend these observations and study how fats with widely differing n3 and n6 poly-unsaturated fatty acid contents influence IL1, interleukin 6 and TNF production by macrophages. The cellular and molecular mechanisms by which the modulatory effects of fats act will be studied and will include measurement of membrane fluidity, ligand binding, G protein activity and eicosanoid production.
1. To determine whether the modulatory effects of fish oil on interleukin 1 and tumour mecosis factor production during inflammation, extend to other fats typical of human diets. 2. To determine whether interleukin 6 production from immune cells following inflammatory stimuli is influenced by dietary fats. 3. To determine the mechanisms by which fats modify production of the cytokines.
Time-Scale and Cost
From: 1992

To: 1995

Cost: £118,604
Contractor / Funded Organisations
University - Southampton