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NITROFURAN DRUG METABOLISM - Transferred to VMD 1.4.94 - FS2116

Description
THERE IS THE POTENTIAL FOR HUMAN EXPOSURE TO FURAZOLIDONE, A MUTAGEN AND SUPPOSED CARCINOGEN, VIA CONSUMPTION OF MEAT FROM ANIMALS TREATED WITH THIS DRUG. THE COT AND VPC HAVE RECOMMENDED THAT MORE SENSITIVE ANALYTICAL METHODS FOR FURAZOLIDONE AND OTHER NITROFURANS BE DEVELOPED IN ORDER TO INCREASE THE ASSURANCE THAT CONSUMERS ARE NOT EXPOSED TO RESIDUES OF THESE COMPOUNDS. MANY ANIMAL SPECIES RAPIDLY AND COMPLETELY METABOLISE FURAZOLIDONE YET RADIOLABELLED STUDIES INDICATE THAT BOUND RESIDUES PERSIST LONG AFTER ELIMINATION OF THE PARENT DRUG. THE WPVR VIEWS THE DEVELOPMENT AND VALIDATION OF AN ANALYTICAL METHOD SUITABLE FOR ROUTINE SURVEILLANCE AS A HIGH PRIORITY. THIS PROJECT AIMS TO ISOLATE AND IDENTIFY MARKER RESIDUE (S) FOR FURAZOLIDONE AND WOULD PROVIDE THE BASIS FOR A ROUTINE METHOD.
Objective
A SYSTEMATIC STUDY OF FURAZOLIDONE ADDUCT FORMATION USING N VITRO SYSTEMS WILL ALLOW THE IDENTIFICATION OF ANY MEDIATOR OR INDIRECT MARKER OF CONVALENT BINDING OF FURAZOLIDONE METABOLITES IN EDIBLE TISSUES. THE DEVELOPMENT OF A SENSITIVE ANALYTICAL METHOD FOR SUCH A MARKER RESIDUE IS THE FINAL OBJECTIVE.
Time-Scale and Cost
From: 1992

To: 1994

Cost: £45,940
Contractor / Funded Organisations
University - Manchester
Keywords