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NITROFURAN DRUG METABOLISM - Transferred to VMD 1.4.94 - FS2116
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Description
THERE IS THE POTENTIAL FOR HUMAN EXPOSURE TO FURAZOLIDONE, A
MUTAGEN AND SUPPOSED CARCINOGEN, VIA CONSUMPTION OF MEAT
FROM ANIMALS TREATED WITH THIS DRUG. THE COT AND VPC HAVE
RECOMMENDED THAT MORE SENSITIVE ANALYTICAL METHODS FOR
FURAZOLIDONE AND OTHER NITROFURANS BE DEVELOPED IN ORDER TO
INCREASE THE ASSURANCE THAT CONSUMERS ARE NOT EXPOSED TO
RESIDUES OF THESE COMPOUNDS. MANY ANIMAL SPECIES RAPIDLY AND
COMPLETELY METABOLISE FURAZOLIDONE YET RADIOLABELLED
STUDIES INDICATE THAT BOUND RESIDUES PERSIST LONG AFTER
ELIMINATION OF THE PARENT DRUG. THE WPVR VIEWS THE
DEVELOPMENT AND VALIDATION OF AN ANALYTICAL METHOD SUITABLE
FOR ROUTINE SURVEILLANCE AS A HIGH PRIORITY. THIS PROJECT
AIMS TO ISOLATE AND IDENTIFY MARKER RESIDUE (S) FOR
FURAZOLIDONE AND WOULD PROVIDE THE BASIS FOR A ROUTINE
METHOD. |
Objective
A SYSTEMATIC STUDY OF FURAZOLIDONE ADDUCT FORMATION USING N
VITRO SYSTEMS WILL ALLOW THE IDENTIFICATION OF ANY MEDIATOR
OR INDIRECT MARKER OF CONVALENT BINDING OF FURAZOLIDONE
METABOLITES IN EDIBLE TISSUES. THE DEVELOPMENT OF A
SENSITIVE ANALYTICAL METHOD FOR SUCH A MARKER RESIDUE IS THE
FINAL OBJECTIVE. |
Time-Scale and Cost
From:
1992
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To:
1994
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Cost: £45,940 |
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Contractor / Funded Organisations
University - Manchester |
Keywords
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