Return to Science Search homepage
Return to Project List
|
Fermentation of complex carbohydrates to short chain fatty acids - modification of colonic mucosal damage. - AN0306
|
Description
The importance of fermentation of complex carbohydrates to
short chain fatty acids (SCFA) in the development of early
neoplastic lesions in the colon will be investigated. Germ
free rats will be nono-associated with anaerobic bacteria
from the human gut which ferment carbohydrates predominantly
to one type of SCFA (acetic, propionic or butyric) or to
lactic acid. The effect of SCFA on cell proliferation in the
colon mucosa and on number and size of carcinogens-induced
aberrent crypt foci (early markers of neoplastic damage in
the colon) will be assessed. The project will provide
information on which dietary sources of complex
carbohydrates are likely to provide the greatest health
benefits with respect to colon cancer. |
Objective
1. To assess the ability of SCFA, generated by bacterial
fermentation of indigestible carbohydrates in the colon, to
modify events in colonic neoplasia.
2. To identify which of the various SCFA are the most
effective in modifying colonic neoplasia. |
Time-Scale and Cost
From:
1993
|
To:
1996
|
|
Cost: £268,761 |
|
Contractor / Funded Organisations
BIBRA Toxicology International |
Keywords
|