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Fermentation of complex carbohydrates to short chain fatty acids - modification of colonic mucosal damage. - AN0306

The importance of fermentation of complex carbohydrates to short chain fatty acids (SCFA) in the development of early neoplastic lesions in the colon will be investigated. Germ free rats will be nono-associated with anaerobic bacteria from the human gut which ferment carbohydrates predominantly to one type of SCFA (acetic, propionic or butyric) or to lactic acid. The effect of SCFA on cell proliferation in the colon mucosa and on number and size of carcinogens-induced aberrent crypt foci (early markers of neoplastic damage in the colon) will be assessed. The project will provide information on which dietary sources of complex carbohydrates are likely to provide the greatest health benefits with respect to colon cancer.
1. To assess the ability of SCFA, generated by bacterial fermentation of indigestible carbohydrates in the colon, to modify events in colonic neoplasia. 2. To identify which of the various SCFA are the most effective in modifying colonic neoplasia.
Time-Scale and Cost
From: 1993

To: 1996

Cost: £268,761
Contractor / Funded Organisations
BIBRA Toxicology International