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Assimilation of glucose from different dietary starches: development and application of a new stable isotope approach - AN0305
A new dual-stable isotopic tracer technique will be
developed for investigation in adult humans of the pattern
of assimilation of glucose from starchy foods of different
botanical origin and different processing. The influence of
site of glucose absorption on glucose kinetics and
metabolism will be investigated as part of the development.
Several hypotheses will then be tested: that botanical
source and processing effects rates of glucose influx into
the circulation, that botanical source and processing
affects the pattern of glucose assimilation other that due
to the digestibility of its starch, that a subjects ability
to absorb starches is greater at the first than at the third
meal of the day, that normal individuals differ in their
ability to assimilate starches, that rapidly digestible
starchy food result in a systemic metabolism that would
reinforce a predisposition to metabolic complications, that
adaptation to poorly digested starchy foods lessens any
potential beneficial effects, that adaptation to poorly
digestible starchy foods is detrimental to the tolerance of
rapidly digestible starchy foods.
1. To provide a new quantitative technique using stable
isotopes to assess the nutritional properties of starch
presented in starchy foods.
2. To apply the technique to starchy foods of different
botanical origin and different processing in order to
characterise the nutritional properties of the starchy foods
in detail in man.
3. To determine whether rapidly digestible starchy foods
perturb carbohydrate and lipid metabolism and whether
adaptation to slowly digestible starchy foods obviates (or
enhances) the perturbation.
Time-Scale and Cost
Contractor / Funded Organisations
IFR - Institute of Food Research (BBSRC)