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Determining dietary vitamin K intake and food sources: seasonal variation and biochemical status. - AN0504

Using unique information on the vitamin K composition of individual foods, a complete data-set of vitamin K values for composite dishes will be compiled and integrated into a programme for dietary analysis. These data will be used to determine average daily intake and seasonal variation of vitamin K in male and female volunteers from 7-day weighed food records and food frequency questionaires. The foods which are the major contributors to vitamin K intake will be identified and the relationship between dietary intake and biochemical status will be characterised by the parallel measurement of plasma K and factor VII levels. The potential modifying effects of smoking on vitamin K intake and blood levels will be evaluated and vitamin K will be characterised with respect to its (hypothesised) antioxidant activity.
1. To compile a comprehensive data-set of the vitamin K composition of foods commonly consumed in the UK, and to integrate them into the Microdiet food analysis programme. 2. To determine the daily and seasonal variation in vitamin K intake from food and drink in male and female smokers and non-smokers. 3. To determine the seasonal variation in plasma vitamin K levels in male and female smokers and non-smokers. 4. To define the relationship between dietary intake of vitamin K status. 4. To determine whether vitamin K has any antioxidant activity in vitro.
Time-Scale and Cost
From: 1993

To: 1997

Cost: £138,368
Contractor / Funded Organisations
University - Dundee